A versatile RNA vector for delivery of coding and noncoding RNAs

Schmid, S., Zony, L. C. and tenOever, B. R.

J Virol 07/12/2013

PMID: 24307584

Abstract

The discovery that RNA viruses, lacking any DNA intermediate, can be engineered to express both coding and noncoding RNAs suggests that this platform may have therapeutic value as a delivery vehicle. Here we illustrate that a self-replicating, noninfectious RNA, modeled on influenza virus, provides one such example of a versatile in vivo delivery system for silencing and/or expressing a desired RNA for therapeutic purposes.