Benjamin tenOever

Principal Investigator

Ben completed his postdoctoral formation in Molecular Biology from Harvard University in 2007 after receiving his PhD in Medicine from McGill University in 2004. This training was subsequently applied to the study of host and pathogen interactions, with a focus on the molecular biology of virus infection.


In August of 2007, Dr. tenOever joined the Icahn School of Medicine at Mount Sinai as an Assistant Professor of Microbiology. He is now a Fishberg Professor of Medicine, an Icahn Professor of Microbiology, and the Director of the Virus Engineering Center for Therapeutic and Research (VECToR) at Mount Sinai. He is a 2008 Pew Scholar, a recipient of the 2009 Presidential Award in Science and Engineering, a 2010 recipient of the American Society of Microbiology Young Investigator Award, a 2011 Cozzarelli Prize winner, and he received the Burroughs Wellcome Award for Investigators in the Pathogenesis of Infectious Disease. From 2012 to 2013, he was honored with Outstanding Young Investigator Awards from the American Society of Gene and Cell Therapy and the American Society of Virology. He was also named a finalist for the Vilcek Award for creative promise and served as a US Ambassador of Science in France as a Distinguished Chair of the Fulbright Commission in 2015/2016. Most recently he was honored with a 2017/2018 Innovator Prize by the Pew Charitable Trust.


Non-cell autonomous disruption of nuclear architecture as a potential cause of COVID-19 induced anosmia. 

Zazhytskka M, Kodra A, Hoagland DA, Frere J, Fullard JF, Shayya H, McArthur NG, Moeller R, Uhl S, Omer AD, Gottesman ME, Firestein S, Gong Q, Canoll PD, Goldman JE, Roussos P, tenOever BR, Overdevest JB, Lomvardas S.

Cell 01/02/2022

PMID: Pending

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M.

Nat Cell Biol 13/01/2022

PMID: 35027731

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Ma L, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Bhardwaj P, Piloco P, Rubio-Navarro A, Uhl S, Carrau L, Houhgton S, Redmond D, Shukla AP, Goyal P, Brown KA, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM, Lo JC.

Cell Metablism 07/12/2021

PMID: 34879241

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

Si L, Bai H, Oh CY, Zhang T, Hong F, Jiang A, Ye Y, Jordan TX, Logue J, McGrath M, Belgur C, Nurani A, Cao W, Prantil-Baun R, Gygi SP, Powers RK, Frieman M, tenOever BR, Ingber DE.

bioRxiv 22/11/2021

PMID: 34845453