Christina Higgins

Graduate Student

Bachelor of Science in Microbiology, University of Wisconsin – Madison


Christina is a third year PhD student in the tenOever Lab. Christina completed her B.S. degree in Microbiology at the University of Wisconsin – Madison where she studied the nuclear-cytoplasmic translocation of HIV-1 mRNA in the laboratory of Dr. Nathan Sherer. Between undergraduate and graduate school, she worked as an Associate Research Specialist in the laboratory of Dr. Andrew Mehle studying protein-protein interactions relevant to Influenza A virus. In the tenOever Lab, she studies kinase signaling pathways important for SARS-CoV-2 replication.


The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication

Nilsson-Payant BE, Uhl S, Grimont A, Doane AS, Cohen P, Patel RS, Higgins CA, Acklin JA, Bram Y, Chandar V, Blanco-Melo D, Panis M, Lim JK, Elemento O, Schwartz RE, Rosenberg BR, Chandwani R, tenOever BR

J Virol. 2021 Sep 15:JVI0125721 15/09/2021

PMID: 34523966

Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs

Vy Tran, Mitchell P Ledwith, Thiprampai Thamamongood, Christina A Higgins, Shashank Tripathi, Max W Chang, Christopher Benner, Adolfo García-Sastre, Martin Schwemmle, Adrianus C M Boon, Michael S Diamond, Andrew Mehle

Nat Microbiol. 2020 Dec;5(12):1490-1503 24/08/2020

PMID: 32839537

EPS8 Facilitates Uncoating of Influenza A Virus

Larson GP, Tran V, Yú S, Caì Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A

Cell Rep. 2019 Nov 19;29(8):2175-2183.e4 19/11/2019

PMID: 31747592

Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export

Ryan T Behrens, Mounavya Aligeti, Ginger M Pocock, Christina A Higgins, Nathan M Sherer

J Virol. 2017 Jan 18;91(3):e02107-16. 18/01/2017

PMID: 27852860