Team

Tristan X. Jordan

Postdoctoral Fellow
EDUCATION AND TRAINING

BIOGRAPHY

Tristan is a postdoctoral fellow with interests in the cell biology of virus-host interactions and the evolutionary pressures exerted on RNA viruses by different antiviral systems. He currently works to a) adapt different RNA dependent RNA polymerases to mammalian systems in addition to engineering a toolbox of viruses to elucidate various aspects of the host response to virus infection, b) understand how Drosha restricts positive strand RNA viruses, and c) the structure and function of the replicative organelles elaborated by (+)-RNA viruses. During graduate school, he worked in the lab of Glenn Randall where he focused on understanding how dengue virus modulates cellular signaling pathways to initiate a proviral, lipid droplet-specific autophagy


PUBLICATIONS

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.

Longlong Si # 1, Haiqing Bai # 1, Melissa Rodas 1, Wuji Cao 1, Crystal Yuri Oh 1, Amanda Jiang 1 2, Rasmus Moller 3, Daisy Hoagland 3, Kohei Oishi 3, Shu Horiuchi 3, Skyler Uhl 3, Daniel Blanco-Melo 3, Randy A Albrecht 3, Wen-Chun Liu 3, Tristan Jordan 3, Benjamin E Nilsson-Payant 3, Ilona Golynker 3, Justin Frere 3, James Logue 4, Robert Haupt 4, Marisa McGrath 4, Stuart Weston 4, Tian Zhang 5, Roberto Plebani 1 6, Mercy Soong 1, Atiq Nurani 1, Seong Min Kim 1, Danni Y Zhu 1, Kambez H Benam 1 7 8, Girija Goyal 1, Sarah E Gilpin 1, Rachelle Prantil-Baun 1, Steven P Gygi 5, Rani K Powers 1, Kenneth E Carlso n 1, Matthew Frieman 4, Benjamin R tenOever 3, Donald E Ingber 9 10.

Nature Biomedical Engineering 03/05/2021

PMID: 33941899

TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation

Ho JSY, Mok BW, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Zhang AJ, Lee AC, Liu WC, Jangra S, Escalera A, Aydillo T, Melo BS, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Miraldi ER, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I.

Cell 30/03/2021

PMID: 33836156

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

Daniloski Z, Jordan TX, Ilmain JK, Guo X, Bhabha G, tenOever BR, Sanjana NE.

Elife 11/02/2021

PMID: 33570490

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells

Daniloski Z, Jordan TX, Wessels HH, Hoagland DA, Kasela S, Legut M, Maniatis S, Mimitou EP, Lu L, Geller E, Danziger O, Rosenberg BR, Phatnani H, Smibert P, Lappalainen T, tenOever BR, Sanjana NE.

Cell 07/01/2021

PMID: 33147445