Team
EDUCATION AND TRAINING
BIOGRAPHY
I am a graduate of a liberal arts college (The College of Wooster) and did my PhD at the University of Chicago where I studied the modulation of lipid metabolism by dengue virus. In 2017, I came to the tenOever lab where I had two major areas of focus: 1) how viruses manipulate cellular machinery to facilitate their replication; and 2) how the cell regulates the antiviral interferon response. Ben’s interest in the evolution of antiviral systems infected me early on, and inspired me to pursue a third area of research in my current lab: determining the antiviral systems of protists, how the giant viruses that infect them navigate these defenses, and what this has to say about the evolution of antiviral systems in higher eukaryotes.
PUBLICATIONS
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.
Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin TY, Liberatore KM, Bulaon DK, Van Nest SJ, Koundouros N, Kastenhuber ER, Mercadante MN, Shobana-Ganesh K, He L, Schwartz RE, Chen S, Weinstein H, Elemento O, Piskounova E, Nilsson-Payant BE, Lee G, Trimarco JD, Burke KN, Hamele CE, Chaparian RR, Harding AT, Tata A, Zhu X, Tata PR, Smith CM, Possemato AP, Tkachev SL, Hornbeck PV, Beausoleil SA, Anand SK, Aguet F, Getz G, Davidson AD, Heesom K, Kavanagh-Williamson M, Matthews DA, tenOever BR, Cantley LC, Blenis J, Heaton NS
Science Signaling, 15(757):eabm08. 25/10/2022
PMID: 36282911
Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity
Si L, Bai H, Oh CY, Zhang T, Hong F, Jiang A, Ye Y, Jordan TX, Logue J, McGrath M, Belgur C, Nurani A, Cao W, Prantil-Baun R, Gygi SP, Powers RK, Frieman M, tenOever BR, Ingber DE.
bioRxiv 22/11/2021
PMID: 34845453
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Longlong Si # 1, Haiqing Bai # 1, Melissa Rodas 1, Wuji Cao 1, Crystal Yuri Oh 1, Amanda Jiang 1 2, Rasmus Moller 3, Daisy Hoagland 3, Kohei Oishi 3, Shu Horiuchi 3, Skyler Uhl 3, Daniel Blanco-Melo 3, Randy A Albrecht 3, Wen-Chun Liu 3, Tristan Jordan 3, Benjamin E Nilsson-Payant 3, Ilona Golynker 3, Justin Frere 3, James Logue 4, Robert Haupt 4, Marisa McGrath 4, Stuart Weston 4, Tian Zhang 5, Roberto Plebani 1 6, Mercy Soong 1, Atiq Nurani 1, Seong Min Kim 1, Danni Y Zhu 1, Kambez H Benam 1 7 8, Girija Goyal 1, Sarah E Gilpin 1, Rachelle Prantil-Baun 1, Steven P Gygi 5, Rani K Powers 1, Kenneth E Carlso n 1, Matthew Frieman 4, Benjamin R tenOever 3, Donald E Ingber 9 10.
Nature Biomedical Engineering 03/05/2021
PMID: 33941899
TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation
Ho JSY, Mok BW, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Zhang AJ, Lee AC, Liu WC, Jangra S, Escalera A, Aydillo T, Melo BS, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Miraldi ER, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I.
Cell 30/03/2021
PMID: 33836156