Viruses require a host cell to obtain the energy and raw materials to replicate and spread. In response, the cell encodes a number of antiviral programs aimed at inhibiting all of the processes necessary for the virus to complete its life cycle. Through countless rounds of evolutionary selection, the interaction between virus and host is complex. In general, all viruses that cause disease do so as a result of antagonising some aspect of the cellular defense systems. For this reason, we study how viruses and cells interact to better understand the underlying biology responsible for the pathogenesis caused by a given virus.