Team
EDUCATION AND TRAINING
Ph.D. in molecular and cellular biology focusing on the human antiviral response from the University of Strasbourg (France) and M.Sc. in molecular biology and genetics from the University of Strasbourg (France).
BIOGRAPHY
I am a French molecular and cellular biologist who is working on the mammalian antiviral response against emerging viruses. During my PhD, I worked on the involvement of the Dicer protein from the RNA interference pathway in the human antiviral response against alphaviruses. I could show that Dicer interacts with actors from the mammalian type I interferon response and that its helicase domain limits the constitutive activation of this immune pathway. This reinforced the idea of a cross-talk between the two antiviral responses in mammals.
PUBLICATIONS
The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways
Baldaccini M, Gaucherand L, Chane-Woon-Ming B, Messmer M, Gucciardi F, Pfeffer S.
EMBO J. 2024 Mar;43(5):806-835. 29/01/2024
PMID: 38287188
RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication
Brugier A, Hafirrassou ML, Pourcelot M, Baldaccini M, Kril V, Couture L, Kümmerer BM, Gallois-Montbrun S, Bonnet-Madin L, Vidalain PO, Delaugerre C, Pfeffer S, Meertens L, Amara A. RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication. J
Virol. 2022 Apr 13;96(7):e0196221. 10/03/2022
PMID: 35266803
Untangling the roles of RNA helicases in antiviral innate immunity
Baldaccini M, Pfeffer S.
2021 Dec 9;17(12):e1010072. 09/12/2021
PMID: 34882751
Human DICER helicase domain recruits PKR and modulates its antiviral activity
Montavon TC, Baldaccini M, Lefèvre M, Girardi E, Chane-Woon-Ming B, Messmer M, Hammann P, Chicher J, Pfeffer S.
PLoS Pathog. 2021 May 13;17(5):e1009549. 13/05/2021
PMID: 33984068