Team
EDUCATION AND TRAINING
BIOGRAPHY
Dr. Carrau is a Uruguayan virologist with main expertise in emerging viruses and virus evolution. During her PhD she worked in in vitro and in vivo experimental evolution approaches on the picornavirus Coxsackievirus B3 and in the alphavirus chikungunya virus. This work led to the development of a novel live attenuated vaccine against chikungunya virus. For her next project she worked in the emerging arboviruses Mayaro and Usutu virus, considered to have high potential to cause outbreaks in the human population. In 2020 she joined the tenOever lab as a postdoctoral fellow, working mainly on animal models to study the host response and therapeutics against SARS-CoV-2.
PUBLICATIONS
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
Han Y, Tan L, Zhou T, Yang L, Carrau L, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D; NYSCF Global Stem Cell Array Team; Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T, Chen S.
10.1016/j.stem.2022.09.008 06/10/2022
PMID: 36206731
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
Paôline Laurent, Chao Yang, André F Rendeiro, Benjamin E Nilsson-Payant, Lucia Carrau, Vasuretha Chandar, Yaron Bram, Benjamin R tenOever, Olivier Elemento, Lionel B Ivashkiv, Robert E Schwartz, Franck J Barrat
10.1126/sciimmunol.add4906 09/09/2022
PMID: 36083891
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M.
Nat Cell Biol 13/01/2022
PMID: 35027731
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2
Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Ma L, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Bhardwaj P, Piloco P, Rubio-Navarro A, Uhl S, Carrau L, Houhgton S, Redmond D, Shukla AP, Goyal P, Brown KA, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM, Lo JC.
Cell Metablism 07/12/2021
PMID: 34879241
